A preclinical research company (CRO) in immunology and pharmacology

Acute experimental encephalomyelitis (MS model)

Immunization of mice with neural MOG peptide together with (FCA and PTX as adjuvants causes severe neuroinflammation with progressive motor symptoms and paralysis.
MOG immunized young female BL6 mice develop progressive neurological signs with paresis and paralysis and loss of body weight. Dexamethasone inhibits efficiently the automimmune disease as is used as a positive control.
Mice are sacrificed on day 24 for cytokine/chemokine production and microscopic analysis: IL-1 and the chemokines CCL2 and CCL5 are significantly increased in the brain homogenates, and a distinct inflammation is found in the spinal cord.

Cerebral malaria

Cerebral malaria is a still a major cause of children with malaria infection which develops rapidly and no treatment exist for this syndrome. Using P. berghei ANKA we model both sporozoite and blood stage infection with acute T cell recruitment and a microvascular disease which is lethal in BL6 mice (Togbe et al PlosOne 2008, Am HJ Pathol 2007 and Fauconnier Am J Pathol 2010). The model has allowed to identify several pathways which confer resistance and to test novel inhibitor of CM development.